abstract |
The present invention relates to a compound of formula 1 or 2 n nwherein R 1 represents straight-chain or branched C 2 -C 8 alkyl, C 2 -C 8 alkenyl, optionally substituted by at least one substituent selected from the group consisting of hydroxyl, amino or C 1 -C 6 alkyl amino group, or C 2 -C 4 alkynyl, optionally substituted by at least one substituent selected from the group consisting of hydroxyl, amino or C 1 -C 6 alkyl amino group; and R 2 represents hydroxyl, C 1 -C 6 alkyl, C 1 -C 6 alkylcarbonyl, di(C 1 -C 6 -alkyl)aminomethyl, C 3 -C 6 heterocyclylmethyl or arylaminomethyl, wherein the aryl group is optionally substituted by at least one substituent selected from the group consisting of halogens and C 1 -C 6 alkoxy as well as associated pharmaceutical compositions and uses of the compound or composition in therapy, in particular for the treatment of a disorder or a disease susceptible to inhibition of COX-2. |