| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4dcc7d7259def30e33dbf2ba33a42672 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01099
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21069
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6462
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2451
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6459
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-75
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-8132 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-75 |
| filingDate |
2013-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a6e1fb8c462f878eef6028a0ff8cad2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5bbdc08ae9d68eac27c68547dff95e17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b4017a0f764919fbd7b68848e11b26f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_219a1ca805255f6a4ca65ed6e2ab534e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acc65175be2d1a791c365aa933fc53b0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8179656be81a6399eb06e7a4b5b7dd13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75066b912ca3da424b7f04255d9e75e6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5435e7a7331d50798342d01d5a7576e6 |
| publicationDate |
2014-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8828686-B2 |
| titleOfInvention |
Polynucleotides encoding therapeutic inhibitors of PAI-1 |
| abstract |
The invention relates to mammalian PAI-I ligands and modulators. In particular, the invention relates to polypeptides, polypeptide compositions and polynucleotides that encode polypeptides that are ligands and/or modulators of PAI-I. The invention also relates to polyligands that are homopolyligands or heteropolyligands that modulate PAI-I activity. The invention also relates to ligands and polyligands localized to a region of a cell. The invention also relates to localization tethers and promoter sequences that can be used to provide spatial control of the PAI-I ligands and polyligands. The invention also relates to inducible gene switches that can be used to provide temporal control of the PAI-I ligands and polyligands. The invention also relates to methods of treating or preventing atherosclerosis. The invention also relates to methods of treating or preventing fibrosis. |
| priorityDate |
2008-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |