| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a6638ac6b1020cd2c62d09d748bc1ab9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0d6c38c9ce4f5e90b419ba5c9b76e56b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fec576c38e34882531ca37d6b922bf42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_58756667af263f764c61ba30729d16d5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_608dc04fcc592c7d9ebe65f7aa380890
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4b9d1f452992131d2a1d418307742ba6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_73be623f51f179e5d37cc29888b36cfa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac3e74d03fcf026ca479215953b37f2c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-0266
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-824
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2231-32 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-223
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-2409
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-04 |
| filingDate |
2010-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7b42512f3c8637f4b73143794ff69e8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c7221861abeaa9076ea3a49412c3470
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b06ae336d24ced87d30a90765ce2fec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45a30b521f71f1d8dc48c7c3c0dc9a24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6a8ec1fa4833f60f19bdc6deb383135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_262b6d8d7a4b72481b7d5bbdf2271ff2 |
| publicationDate |
2014-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8809557-B2 |
| titleOfInvention |
Method for producing optically active fluorinated oxetane |
| abstract |
Disclosed is a method of producing an optically active fluorinated oxetane, which can be an important pharmaceutical or agricultural intermediate, by reaction of a fluorinated α-keto ester with an acyl alkenyl ether in the presence of a transition metal complex with an optically active ligand. This method utilizes a catalytic asymmetric synthesis process and does not require a stoichiometric amount of chiral source. It is thus possible to dramatically reduce the amount of use of the asymmetric catalyst especially when the reaction is performed at a high concentration of substrate (with the use of a small amount of reaction solvent) or in the absence of a reaction solvent (under neat conditions). Further, the target optically active fluorinated oxetane can be obtained with high yield and with very high optical purity. The product contains almost no difficult-to-separate impurity and shows high chemical purity. |
| priorityDate |
2009-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |