| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_683b50e847b6915f6c8b998c379fdf04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f398f038d89b1e57c85178ec42cf4c8b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03785b3e90a7085de9491f460ec47460
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b09f893b262cefd50c5e76c4b85d1c0a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4463af920395498b0c29b556baf50afa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14ebe1c89a6b9ece4eaef6b8b1bbbf88 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F112-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-062
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06086
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K17-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-068 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-068 |
| filingDate |
2011-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_382fd3aac8206a0446357f91740c8562
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0a830cd268f279f4dce7fe95f3ad30e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a447067f5332577f2629d2a84a9eee7e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a659e3f97bb42486ed06f25822f978ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb0ec854c8f55a95d77e6339e4f5484d |
| publicationDate |
2014-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8802819-B2 |
| titleOfInvention |
Diketopiperazine forming dipeptidyl linker |
| abstract |
The invention relates to a method for homogeneous solution phase peptide synthesis (HSPPS) of a N-terminal peptide fragment PEP-N and a C-terminal peptide fragment C-PEP, with C-PEP carrying a specific diketopiperazine (DKP) comprising C-terminal protecting group, which contains a handle group HG, with HG being connected to the C-terminus of the peptide fragment; thereby this specific DKP comprising C-terminal protecting group can be selectively cleaved from the peptide as a conventionally used C-terminal protecting group. By the use of this DKP and HG comprising C-terminal protecting group, certain process steps in convergent peptide synthesis based on a combination of HSPPS and solid phase peptide synthesis (SPPS) can be avoided. The invention relates further to a method for the preparation of such specifically protected fragment C-PEP by SPPS by using a linker comprising a specific dipeptide and HG for connecting the growing peptide chain to the resin, which linker forms said DKP group, when the peptide fragment C-PEP is cleaved from the supporting resin; and further to the intermediates of the preparation method. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10450343-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10087221-B2 |
| priorityDate |
2010-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |