| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_45858ad8420337cf54fe6ca9ecc17337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e65ba57390a9b22cff12e1ade78c8ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05b993887652163a78a888d6e7e41ae7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7db088a1cef40f4f0e03a2468c1fefac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf2380e07172f31e9723231d4794ad87
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a742ed559a188e3cb187177027829a1a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N61-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-00 |
| filingDate |
2008-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eeda6f049df68386b0b95515d785e52e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77a928ee459f54c943493a6bca708449
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9e6a5cf1fb139d842100ea7bbb25802
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_382a7e5eb0113eeba586b8a6270c453c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_572663206606a9b4cc82e1262bf12992 |
| publicationDate |
2014-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8802631-B2 |
| titleOfInvention |
Peptides and methods for the treatment of gliomas and other cancers |
| abstract |
The invention is based on the discovery that STM/Hop promotes proliferation of human glioblastoma-derived cells but not of normal astrocytes and that the proliferation requires the binding of STM/Hop to PrP c . The invention is directed to methods for treating cancer which rely on interfering with the Hop-PrP c interaction and to peptides, and antibodies raised against the peptides, which directly provide that interference. The invention is further based on the discovery that STI1 230-245 peptide and its human homologue Hop23o-245 provide the desired interference with the STI1/Hop-PrP c interaction and inhibit the STI 1/Hop-induced proliferation of glioma and glioblastoma cells. The invention is thus further directed to methods of treating cancer that employ these peptides and functional derivatives thereof, and antibodies directed to the peptides and derivatives. The invention is further directed to means of treating cancer which involve reducing the effective amount of Hop or reducing the expression of Hop. The invention is further directed to means of alleviating or eliminating the side effects of drug therapy and radiotherapy used in treating patients with brain cancers. |
| priorityDate |
2007-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |