| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8c0982b0f02b1ed6d20a315370a3a3a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da1b1a6a1ef761b5de297086203795e8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ae6ba5a9ceb2778077ba6125ed3d855d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_946eebca9bce5435fd9f264ec057526c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6891
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-439
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4196
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 |
| filingDate |
2010-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd11d081b520bbb4996115af70231436
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea0e5a6b82068fe316dd4c2a3712bd3b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9509bd971a855b1ca1f471d89a9884bc |
| publicationDate |
2014-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8765920-B2 |
| titleOfInvention |
Tyrosine bioconjugation through aqueous Ene-like reactions |
| abstract |
A new and versatile class of cyclic diazodicarboxamides that reacts efficiently and selectively with phenols and the phenolic side chain of tyrosine through an Ene-like reaction is reported. This mild aqueous tyrosine ligation reaction works over a broad pH range and expands the repertoire of aqueous chemistries available for small molecule, peptide, and protein modification. The tyrosine ligation reactions are shown to be compatible with the labeling of native enzymes and antibodies in buffered aqueous solution. This reaction provides a novel synthetic approach to bispecific antibodies. This reaction will find broad utility in peptide and protein chemistry and in the chemistry of phenol-containing compounds. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019182942-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019199628-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11530250-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10973920-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10973922-B2 |
| priorityDate |
2009-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |