| abstract |
Provided herein are compounds of formula (I):n nA-L-B  (I)n nand pharmaceutically acceptable salts and stereoisomers thereof, wherein A isn n nwherein X is (i) CR 1 or N, or (ii) O or NR 2 , each Y is independently N or CR 3 , and each Z is independently N or C, wherein R 1 , R 2 and R 3 are defined in the specification; L is a linker, and B is a multicyclic ring; methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are inhibitors of phosphodiesterases and useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, e.g., neurological disorders, psychosis, schizophrenia, obesity and diabetes. |