http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8765122-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff81a650b70e913d3b2524b45e4c7320 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e673efcc8910e11423cc5dffaadf93e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2bddb0ab844379ea3d3bccc4dead458 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ad34545894ee2c6db43c71be8770c5ab http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_57ccdb0f181d80e5c2199b5823285d67 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5153 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1647 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46 |
| filingDate | 2010-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d12f828221fa232b4e29d7905189c65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9de3d35f0b02732f54b32c2b737b863d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98a5966d6a8cea4102ef3ef8e9db07b3 |
| publicationDate | 2014-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8765122-B2 |
| titleOfInvention | Nanosphere/microsphere delivery system for the treatment of spinal cord injury |
| abstract | A formulation including injectable biodegradable nanospheres and/or microspheres as a delivery system for chondroitinase ABC (cABC) or a functional derivative of cABC to treat acute and chronic spinal chord injury in a mammal having the same is provided. The biodegradable nanosphere/microsphere formulation releases cABC or a functional derivative of cABC in a time-released manner at the site of the spinal cord injury. cABC infusion can promote axon regrowth and some behavioral recovery. The nanospheres and/or microspheres provided herein include cABC or a functional derivative of cABC loaded within and/or on a biodegradable polymer matrix. In some embodiments of the present invention, the surface of the biodegradable polymer matrix can be modified to target a specific scar site. In addition to providing a nanosphere formulation that include polymeric incorporated cABC, a method of treating a mammal having a spinal cord injury is also provided. |
| priorityDate | 2004-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 458.