| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_648c9679dd9ec36125406a2dafa6bf7e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-79
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-803
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-025 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-40 |
| filingDate |
2012-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c418ff102408add6d3f2bffdac53589
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb42db7360a45cff5d45a6c8bc6a3aae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff5f0fe5a7a284f9943963d61582d29b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4364493062ed2d2405a46a01c3cfd4a |
| publicationDate |
2014-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8754110-B2 |
| titleOfInvention |
Methods of producing methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate |
| abstract |
Methods of producing methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate. One method comprises adding methyl isobutyl ketone to an aqueous solution comprising 4-chloro-2-fluoro-3-methoxyphenyl-boronic acid to form an organic phase comprising the 4-chloro-2-fluoro-3-methoxyphenylboronic acid and an aqueous phase. The organic phase and the aqueous phase are separated. The 4-chloro-2-fluoro-3-methoxyphenylboronic acid is reacted with methyl 4-(acetylamino)-3,6-dichloropyridine-2-carboxylate in methyl isobutyl ketone to produce methyl 4-(acetylamino)-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate, which is deacetylated to produce methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9422313-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015203514-A1 |
| priorityDate |
2011-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |