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filingDate 2011-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2014-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2014-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-8753607-B2
titleOfInvention Methods and kits for the differential diagnosis of Alzheimer's disease versus frontotemporal dementia and for the diagnosis of frontotemporal dementia, comprising FAS-L and CK 18 as biomarkers
abstract The invention relates to methods and kits for the differential diagnosis of Alzheimer's disease (AD) versus frontotemporal dementia (FTD), using biomarkers TNF-α, FAS-L and CK18, taken from a biological sample. Differences in biomarker levels can be used to distinguish between AD and FTD The invention is based on a discovered correlation between FTD and markers FAS-L and CK18. Therefore the invention also relates to the diagnosis of FTD using FAS-L and CK18. The serum concentrations of these biomarkers can further be used as an index of the severity of disease, and may occur in conjunction with clinical-based diagnostic testing and neuro-imaging assessment.
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