| abstract |
Disclosed is a method for preparing a compound of Formula 1 comprising contacting a compound of Formula 2 with at least one compound of Formula 3 in the presence of a solvent comprising one or more organic solvents selected from ethers and nitriles and a catalytically effective amount of a palladium complex comprising at least one tertiary phosphine ligand of Formula 4 n nwherein R 1 is NHR 3 or OR 4 ; R 2 is CH 3 or Cl; R 3 is H, alkyl, cyclopropyl, cyclopropylmethyl or methylcyclopropyl; R 4 is H or C 1 -C 4 alkyl; M 1 is an alkali metal; and R 5 , R 6 and R 7 are defined in the disclosure; provided that when R 2 is Cl, then X is Br. Also disclosed is a method for preparing a compound of Formula 5 wherein R 14 , R 15 , R 16 and Z are as defined in the disclosure using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the aforedescribed method. |