| abstract |
A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of Formula I: n nwherein X wherein X is —CF 3 , Ar is selected fromn n nand R is selected fromn n n n n n n n n n n n n where n n n R′ is L-Lys, D-Lys, β-Ala, L-Lue, L-Ile, Phe, SO 2 CH 2 CH 2 NH 2 , SO 2 NH 2 , Asn, Glu or Gyl, and n R″ is methyl, ethyl, allyl, CH 2 CH 2 OH, CH 2 CN, CH 2 CH 2 CN, CH 2 CONH 2 , |