| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_26a1ff7f166b7ae1a1462082e868eff9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53f13d31d25d838aa1690f4e2f5592b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d9248d147fa3c26ff6a4e82ce0009203 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-1872
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-1861
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-143333
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2400-0451
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-0822 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6428
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6408
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6458
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-171
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6813
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L3-50273 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01J1-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2009-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d19b6041789e2ff5d1aa403f9982ebe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56cc2feb0595a7b3138a041851ed6633 |
| publicationDate |
2014-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8741570-B2 |
| titleOfInvention |
Thermo-optical characterisation of nucleic acid molecules |
| abstract |
The present invention pertains to a method and a device for the determination of thermo-optical properties, particularly the size or size distribution, of fluorescently labeled biomolecules or biomolecule complexes, particularly nucleic acids, in a reaction solution. The method comprises the steps of: (i) providing a reaction solution with fluorescently labeled biomolecules or biomolecule complexes; (ii) irradiating a laser light beam into the solution to obtain a spatial temperature distribution in the solution around the irradiated laser light beam; (iii) exciting fluorescently said fluorescently labeled biomolecules and detecting the fluorescence at two or more defined regions representing different mean temperatures in said spatial temperature distribution, wherein said detection of fluorescence is performed at least once at a predetermined time after the start of the laser irradiation; and (iv) determining the thermo-optical properties, particularly the size or size distribution, of the fluorescently labeled biomolecules or biomolecule complexes from the detected fluorescence intensity or fluorescence intensity distribution. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110846206-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020154436-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10345312-B2 |
| priorityDate |
2008-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |