Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53205f5563c6ff1c02a736a840ab4d3d http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d761f829a76528be769e9128f051eaf http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bcb146c68b67089013b4c7a614504254 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8023a169f596c68ff7485b07e0d1a385 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cd2422be502bae353d1c9fc99670f752 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ce847ec6f3c526d6644de6548083b140 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c88562b491924083cd8fff6a62404b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_385b586b26e431be0c66d80c1fa0084f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_896f3088fe3d13776df6c7aa943f486f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3ebe6af5f762122ebb7c476849ddfc3d |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y113-12007 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0013 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0069 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0045 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-79 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-54 |
filingDate |
2011-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2014-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f285acb3dd26e2de9a039451e89d49d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_818f13b16b17a72ae56593a3deaa590a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1dbf82e27561a99b16b6d5f33edb3e65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c098c1b135358b16fbf10d3f4fff2fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d7f976cc648df8e71aa8b80c7b15a38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5672de1d429c2ca189e0340a3129e7be http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39af416646c075c5b1577bffbd21acee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2d5d937a70b9baa36f920c0aa8773f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b23bc183e071be0bbac210030092942 |
publicationDate |
2014-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-8735559-B2 |
titleOfInvention |
Mutant protease biosensors with enhanced detection characteristics |
abstract |
A polynucleotide encoding a biosensor polypeptide comprising a modified circularly-permuted thermostable luciferase and a linker linking the C-terminal portion of the thermostable luciferase to the N-terminal portion of the thermostable luciferase. The modified circularly-permuted thermostable luciferase is modified relative to a parental circularly-permuted thermostable luciferase. The linker contains a sensor region capable of interacting with a target molecule in a cell. The modified circularly-permuted thermostable luciferase has an enhanced response after interaction of the biosensor with the target molecule relative to the parental circularly-permuted thermostable luciferase in the presence of the target molecule. Alternatively, the modified circularly-permuted thermostable luciferase has an enhanced response after interaction of the biosensor with the target molecule relative to the modified circularly-permuted thermostable luciferase in the absence of the target molecule. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9879306-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9290745-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9248201-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014287433-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9339561-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10077433-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9757478-B2 |
priorityDate |
2010-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |