| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a2828cc7688b838e3cf7022b5f07d4c5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_227e0fc58096573288a87a1264dc09a4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_45759f9449c96ee1489fa58f17d5e4ae |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-988
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-527
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y404-01011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y404-01001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-96
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-60 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-88 |
| filingDate |
2011-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0be27e73aab23633ab488627c4010d2b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d653a46e6e7bae857ddf5d0cceb487f6 |
| publicationDate |
2014-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8709407-B2 |
| titleOfInvention |
Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations thereof |
| abstract |
Methods and composition related to the engineering of a novel protein with methionine-γ-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-γ-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10526638-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9624484-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11584949-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018209192-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10363311-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10716856-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9987241-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10724026-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020086937-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020099592-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10865403-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11033612-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11426464-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10233438-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9481877-B2 |
| priorityDate |
2010-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |