| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37709e1ffc2cb1e60d547654ce1027b2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68c213ba9952360f439567152e047b18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_23507cc6b8f52b137d732700e4812bbc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_29fc20b8da0e462d58822ea03d5a6631
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4d6f297ddc35cdfc3b8d4f6c1e29aa7f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-03 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-215
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-001 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate |
2011-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4de2664b723625d4760ddf63093d3cfe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f9988fae71e5d79dae58a569785afae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c5bacaf468316ef16275634b702a0e8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc9b72de4a5b1789f540c379be1f34ef |
| publicationDate |
2014-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8703909-B2 |
| titleOfInvention |
Selective delivery of molecules into cells or marking of cells in diseased tissue regions using environmentally sensitive transmembrane peptide |
| abstract |
A polypeptide with a predominantly hydrophobic sequence long enough to span a membrane lipid bilayer as a transmembrane helix (TM) and comprising one or more dissociable groups inserts across a membrane spontaneously in a pH-dependant fashion placing one terminus inside cell. The polypeptide conjugated with various functional moieties delivers and accumulates them at cell membrane with low extracellular pH. The functional moiety conjugated with polypeptide terminus placed inside cell are translocated through the cell membrane in cytosol. The peptide and its variants or non-peptide analogs can be used to deliver therapeutic, prophylactic, diagnostic, imaging, gene regulation, cell regulation, or immunologic agents to or inside of cells in vitro or in vivo in tissue at low extracellular pH. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10933069-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11555019-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9814781-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11634508-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11229710-B2 |
| priorityDate |
2005-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |