| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_114e4423ec77cbc8dab9d0a98909704e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bf6447545d9668ef36e0b50f2ed1ad92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_af48c540d95ae411c8035fecc2d142e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_995fb8f1b7a82bd8c67dc7ea85b02af5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_841a75a3585438c3567f9bd875c60467 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-16 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C239-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N37-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-00 |
| filingDate |
2011-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3081310b18714dc47c0fec00b95df64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9924fd498785eb7415329ff80bc9590e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e82f51a56c7880fab5d66fb792c097ff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a6129fa79a1d56b2f5cfa731dd06384 |
| publicationDate |
2014-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8703824-B2 |
| titleOfInvention |
Cationic amphiphiles with mannose-mimicking head-groups and a process for the preparation thereof |
| abstract |
The present invention discloses novel cationic amphiphiles containing mannose-mimicking shikimic and quinic acid head-groups and a process for preparing cationic amphiphiles with mannose-mimicking polar head-groups such as, shikimic and quinic acids. The findings described herein also demonstrate that compounds of the present invention can target model DNA vaccines to antigen presenting cells (APCs) such as macrophages and dendritic cells (DCs), via mannose receptors expressed on the cell surface of APCs. The cationic amphiphiles disclosed herein show enhanced cellular and humoral immune response compared to their mannosyl counterpart in dendritic cell (DC, the most professional APC) based genetic immunization in mice. Cationic amphiphiles with mannose-mimicking quinic and shikimic acid head-groups described in the present invention are likely to find future applications in the field of genetic immunization. |
| priorityDate |
2010-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |