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publicationDate 2014-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-8691882-B2
titleOfInvention Organic-inorganic hybrid scaffolds with surface-immobilized nano-hydroxyapatite and preparation method thereof
abstract Provided are an organic-inorganic hybrid scaffold with surface-immobilized nano-hydroxyapatite, and a method for the fabrication thereof. The scaffold is fabricated by reacting an acid group present on a surface of nano-hydroxyapatite with a primary amine present on a surface of a polymer support in the presence of EDC (1-ethyl-3-dimethylaminopropyl carbodiimide) to immobilize nano-hydroxyapatite onto the surface of the polymer support. The surface of nano-hydroxyapatite is previously grafted with poly(ethylene glycol methacrylate phosphate) (PolyEGMP) having phosphonic acid functionality or with a polymer having carboxylic acid functionality.
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