http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8680155-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fc06cad2b58bbfcc30e3c96a6eb6c926 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fa52a9820a9f0c3eca78fd56e4a0184d http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9edc017ca5ab938ae99016ef9696712a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed1db8d9db39150901bb8dcc4f867b41 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C327-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C251-02 |
| filingDate | 2011-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eaec901516ff704116b85df050d8e6bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b49151d6bc9b876c3f509a99f4833555 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfad7c17786421826bd28f8300b89898 |
| publicationDate | 2014-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8680155-B2 |
| titleOfInvention | Synthesis and antitumor activity of novel bis(benzylidene-benzenamine)disulfides |
| abstract | Novel synthetic bis(benzylidene-benzenamine)disulfides and the preparation method are disclosed in the present invention. These compounds are afforded with the oxidizing reagent at low temperature and short time period via intra-molecular coupling reaction. In vitro experiments have been revealed that bis-disulfides are cytotoxic to cancer cells, especially human breast cancer cells MCF-7. Additionally, bis-disulfides arrest the cell cycle at sub-G1 phase and increase p38 phosphorylation to result in apoptosis. Bis-disulfides also inhibit growth of murine melanoma B16 cells but have no cytotoxicity to human fibroblasts. Bis-disulfides also can reduce murine melanoma size in the mouse model. The prepared compounds of the invention would be applicable in anticancer and anti-tumor therapies. |
| priorityDate | 2011-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 115.