| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c1b28e23a7ee849365d41b9025f98a43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_85f9e14554337bedc66a8fd225e14d98
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_088dc1fbb96705d5debc305f7f8d4686
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c771726e89b709f93b922aba311e8a0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-14532 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-443
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-0059
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-4875
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-0071 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B5-1455 |
| filingDate |
2007-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3df41c0643b8ba71cbfc0b8866e97981
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0a7bbabeaaa91eb810d90114cfc4457
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73f3bd1813c68486a17bf241d5d77bd0 |
| publicationDate |
2014-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8676283-B2 |
| titleOfInvention |
Method and apparatus to compensate for melanin and hemoglobin variation in determination of a measure of a glycation end-product or disease state using tissue fluorescence |
| abstract |
A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual is disclosed. A portion of the skin of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can illuminate the skin and detect responsive light over a time that spans a plurality of cardiac cycles of the individual, which can, as an example, help mitigate the effects of time-varying signals such as those due to hemoglobin. The invention can also determine the amount of light to be directed to the skin, for example by controlling the time that a light source is energized. The amount of illumination light can be determined from a skin reflectance characteristic such as pigmentation or melanin in the skin. Controlling the amount of light directed to the tissue can reduce the dynamic range required of a corresponding optical system, for example by allowing a single system to accurately measure individuals with very light skin and individuals with very dark skin. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11154224-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11375898-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9042967-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11284800-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012283530-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11676276-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11051727-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10438356-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11039768-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11154198-B2 |
| priorityDate |
2002-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |