| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5ca637dc687a011603834c661a175428
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e57ac58c58fe8b9cc7815a06258346b1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_351e22206acb7aad678ea37be7abae0b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_11b4c987b5ab49a487129a41bbde391c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_80cad64a3834830f31abffd7e02dcf61 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C239-00 |
| filingDate |
2010-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d03461267ef5a4ddbff8e1de649b42de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d65fe1da8a4a786efb86ffa03e130821
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c28467544dceda39b436fb2301d9282
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72a47e683c0568b88f6b6c92084f0cc8 |
| publicationDate |
2014-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8664440-B2 |
| titleOfInvention |
Method for preparing aliskiren and its intermediates thereof |
| abstract |
A method for preparing Aliskiren and intermediate thereof, which comprises the following steps: reacting 4-bromo-1-methoxy-2-(3-methoxypropoxy)benzene with magnesium isopropyl chloride and n-BuLi to obtain the compound of formula XXII; reacting the product of methylsulfonylation of the compound of formula XIX with anhydrous LiBr to obtain the compound of formula XXI; obtaining the intermediate of Aliskiren shown as formula XV by reacting the compound of formula XXII with the compound of formula XXI in an ether as the solvent and in the presence of a catalyst containing iron; then reacting the compound of formula XV with the compound of formula VII to obtain the compound of formula XXIII, following removing R 1 from the amino group and obtaining Aliskiren shown as formula I. |
| priorityDate |
2010-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |