Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_15d7385a1d93fc8747ef8ee58cbb1c0c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d21cbff64022f95c237c0bd3ec8656ca http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a6c16a3c16a4928273a47903ff70c611 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2f6a1871fb5e2ad6fcc8a5fba27da239 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2840-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2840-203 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10343 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0058 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-64 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 |
filingDate |
2006-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2014-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_837ded2663cd94a390c892f498b45ff2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97706b91706c7a67b267f3e470885fbd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1427c4b9e69e5e0ee69c03f3c8639b7b |
publicationDate |
2014-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-8658778-B2 |
titleOfInvention |
hTMC promoter and vectors for the tumor-selective and high-efficient expression of cancer therapeutic genes |
abstract |
Promoters that include a tissue-selective promoter sequence and a second promoter sequence operatively coupled to the tissue-selective promoter sequence, wherein the second promoter sequence includes a minimal viral promoter sequence, are disclosed. Nucleic acids and compositions that include these promoter sequences are also disclosed. Also disclosed are methods of improving the function of a tissue-selective promoter, involving operatively coupling a tissue-selective promoter sequence with a second promoter sequence that includes a minimal viral promoter sequence. Also disclosed are methods of delivering a gene into a cell, methods of treating a subject with a hyperproliferative disease, and methods of imaging a cell that involve use of the novel promoter sequences set forth herein. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3826683-A4 |
priorityDate |
2005-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |