http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8653056-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a02f98ec953c8bd12ebc02348d0f8c45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8f11bb967a062874458385247870694a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c31087ba2287ce5a9dc4a8f02cf485e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_46a46d4d64c6829c1e5815892e2aaa22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7307b233757226bbd4ecfb3fceee4f4e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4d67ecfbdda39e8006d6b1f2dde85cd4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_23ecd8eab5850c12403740b5e3a4b8ab http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_45985ee69ce4a7e7c82e74584b08030f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9539987a2c07775750f641fdb1ad93b7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2eb691263b6037930f6faf8f2e71cca |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-0047 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J63-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6951 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 |
| filingDate | 2007-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43faa4df5ffbd9f899fd1d0b05fcdc37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a578c8d81f6b768d6143fa5a264d369 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6531a3b98d803e0873757dd6673f4045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e3988ccda129ca5ab6c2516fdadeacc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9dcc76d6193be4315ee3878377eb535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7ee982ccc3214525cb3f9515a114209 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_799bacb36bce50e38027318b9a9df7b0 |
| publicationDate | 2014-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8653056-B2 |
| titleOfInvention | Method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, a soluble formulation of a pentacyclic or tetracyclic terpenoid and a pharmaceutical composition containing this soluble formulation |
| abstract | The invention relates to a method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, wherein the water-insoluble terpenoid having a free carboxylic, hydroxy or amino functional group is derivatized on this functional group with a substituent selected from the group comprising substituents of general formula Xa bound to the hydroxy group of the terpenoid, wherein Xa is —OC—R—COOH, substituents of general formula Xa bound to the amino group of the terpenoid, wherein Xa is —OC—R—COOH, quarternary ammonium substituents of general formula Xb bound to the carboxy group of the terpenoid, wherein Xb is —(CH2)nN+R3Y—, quarternary ammonium substituents of general formula Xc bound to the carboxy group of the terpenoid, wherein Xc je —(CH2)nR+Y—, substituents of general formula Xd bound to the carboxy group of the terpenoid, wherein Xd represents —R—COOH, glycosylic substituents Xe bound by alpha or beta glycosidic bond to the hydroxy group or to the carboxy group of the terpenoid, wherein Xe is selected from the group comprising glucosyl, galactosyl, arabinosyl, rhamnosyl, lactosyl, cellobiosyl, maltosyl and the 2-deoxyanalogues thereof, and subsequently, the prepared derivative is dissolved in the solution containing water, a cyclodextrin and optionally pharmaceutically acceptable auxiliary substances, forming an inclusion derivative with the cyclodextrin. Object of the invention is further a soluble formulation of a pentacyclic or tetracyclic triterpenoid, containing an inclusion complex of the derivatized pentacyclic or tetracyclic terpenoid with a cyclodextrin, and optionally water and pharmaceutically acceptable auxiliary substances and further a pharmaceutical composition containing the soluble formulation. |
| priorityDate | 2006-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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