| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4920fa6e3aab93ddacb17abbddc47dee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37ca83b701f46b8cef9d03d257e2072f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cd3f3983f71674dda4a95090ce828fc1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_709b4a26ef028713f9b302509eb824d7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7994007226f7acd2e38084e042396e33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d6f7da1e425c8a3ef1da21e08f4c196
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ef590dbf71470640d0818cd57a82a35d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4d57841574de6f39be1bbdedfcf1939f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_abab7673db55b5fce91aea28ad4f0d50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b20bf4e7acb6371d23d34aa573c85847 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-167
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-173
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-167 |
| filingDate |
2008-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c14dfb5acd6f14d68186f9052c8d8389
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78e9877dbbdc30a919f3bf50f648b888
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc10e295390efbd27489fbdd7dbd3da6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fee84d378af9f2a1c2ecefc53445435
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5b3357855bdb38b0c5580e478b3bb00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4346bda14bd310e4872167c6710899b1 |
| publicationDate |
2014-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8637485-B2 |
| titleOfInvention |
5′,-substituted adenosynes preparation thereof and use as inhibitors of S-adenosylmethionine decarboxylase |
| abstract |
The crystal structure of the complex of S-adenosylmethionine methyl ester with hΛdoMetDC F223A, a mutant where the stacking of the aromatic rings of F7, adenine and F223 would be eliminated. The structure of this mutant with the ester shows that the ligand still maintains a syn conformation aided by pi-pi interactions to F7, hydrogen bonds to the backbone of Glu67, and electrostatic interactions. Several series of AdoMet substrate analogues with a variety of substituents at the 8 position of adenine were synthesized and analyzed for their ability to inhibit hAdoMetDC. To understand these results, virtual modeling of the enzyme inhibitor complexes and the crystal structures of human AdoMetDC with 5′-deoxy-5′-[N-methyl-N-[2-(aminooxy)ethyl]amino-8-methyl]adenosine (MAOEMA) and 5′-deoxy-5′-[N-methyl-N-[4-(aminooxy)butyl]amino-8-ethyl]adenosine (MAOBEA) at the active site have been determined experimentally. |
| priorityDate |
2007-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |