| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c928a707958f9b96e8cf3d9abf3b3e0b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cdeb4f8cf55692ab468225206816b6ef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e51e6b12f5732dc7aaa81794b2f4d8b4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_41cb5b46e55d899fb3c439a2dc9ca771 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2011-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c19ab4139c436d2700d1e73e76d3bcca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2832f96ed1cc888729a21764be9ecdd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b05e2776cd9d299e1a0b9178c094e4ab |
| publicationDate |
2013-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8617845-B2 |
| titleOfInvention |
Sequence diversity generation in immunoglobulins |
| abstract |
Compositions and methods are disclosed for generating immunoglobulin structural diversity in vitro, and in particular, for reducing biases in V region and J segment gene utilization, and for generating immunoglobulin V-D-J recombination events in a manner that does not require D-J recombination to precede V-DJ recombination. Selection of advantageous combinations of immunoglobulin gene elements, including introduction of artificial diversity (D) segment genes and optimization of recombination signal sequence (RSS) efficiency, are disclosed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10526391-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013236931-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016014725-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I609411-B |
| priorityDate |
2008-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |