Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_57e6ddd3fca0f582f4eba4d9c8c4ceca http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e12b4ce284b5184a276215d70cb6c1a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a564206d8584fa7090db18ff067e7125 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-179 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1825 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
filingDate |
2010-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2013-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf91b1cd570af151e8b2be92fa11ca67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a414a4c028c58a7e14dcdea7b5462911 |
publicationDate |
2013-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-8614183-B2 |
titleOfInvention |
Use of FGFR1 extra cellular domain proteins to treat cancers characterized by ligand-dependent activating mutations in FGFR2 |
abstract |
The present invention relates to the use of Fibroblast Growth Factor Receptor I (FGFR1) extracellular domain (ECD) polypeptides for treatment of cancers characterized by ligand dependent activating mutations in Fibroblast Growth Factor Receptor 2 (FGFR2). For example, the present invention relates to the treatment of endometrial cancers and other cancers wherein tumor cells express FGFR2 mutants in the IgII-IgIII hinge region or IgIII domain of the protein, such as at amino acid positions 252 and/or 253. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11021528-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10724014-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11697678-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11702642-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10294289-B2 |
priorityDate |
2009-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |