http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8603797-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5d6102606047b6fe4b0a687d21600161 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d6f7da1e425c8a3ef1da21e08f4c196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_13798e8d599d04714f67cc3aed5948c3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1024 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-12 |
| filingDate | 2011-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41036adb1c61d8d221e9f74ccbe959e6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e5beaa06aedd307e6aed9c5d42739c7 |
| publicationDate | 2013-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8603797-B2 |
| titleOfInvention | Methods and compositions for targeted mutagenesis in bacteria |
| abstract | This disclosure provides methods and compositions for targeted mutagenesis of specific genes in a bacterial strain. By inducibly over-expressing error-prone polymerases such as Pol IV or Pol V in conjunction with nickase in a bacterial strain, and housing the targeted gene(s) on an episome or plasmid which contains one or more nickase recognition sequences, the targeted gene(s) can be selectively mutated at rates significantly greater than genes contained on the chromosome. The methods disclosed herein are useful for engineering desirable bacterial phenotypes and novel strains, including for example strains useful for treating or degrading waste and/or environmental contaminants, for optimizing bioprocesses, and for converting low-value feed-stock into value-added products. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017019617-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018064338-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10760071-B2 |
| priorityDate | 2010-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 284.