| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3fcb093a174d5182b5854b704cb09354
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_19b62e2a61f4e585f49b07622b03fb4b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2128b1442a71afc21d05805038d3d385
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac583037e3827296aa49b417d03e82b1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8c6a6b080e7c8c5aca82abfb48de3990
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6e9a02a6bac0a919f9c8bb7a848913c5 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-01008 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-16 |
| filingDate |
2012-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_057f2e4e461b1e2612bd45235d6b96a5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96e6bea126a0fd14b3bf4e2dec127949
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab161bb5f041046b4a0a77b210b051f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c41b133b7b7f49257f758019bf27f0bd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3371c0a6eb5d66aef5a2a5e69f5c0d0 |
| publicationDate |
2013-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8592193-B1 |
| titleOfInvention |
High activity mutants of butyrylcholinesterase for cocaine hydrolysis |
| abstract |
Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration. |
| priorityDate |
2011-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |