| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b260a7c056577e479ff564350ca29573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7c487024cc7db63f1ee7d2a0a835cf92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9bceffddb90b9b3da8a772212961764b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24b6e08b34616d3c0bbd3a40fff81821
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3ae5099850610e4d5827ee1c8dc316b5 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-77
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-34 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2008-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_003b848e8375120ae13adc77cb56cd14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed4306966fac8839b64dbe8d548b0d53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_224e325ce3ac42832f519b479342c6f4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3358395ae843fd5c66394a64e8fe2dcc |
| publicationDate |
2013-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8591893-B2 |
| titleOfInvention |
Paratope and epitope of anti-mortalin antibody |
| abstract |
The amino acid sequences of paratope regions involved in internalizing function of an anti-mortalin antibody into tumor cells were determined for the L-chain and H-chain variable regions of cellular internalizing anti-mortalin antibodies and non-internalizing anti-mortalin antibodies. Cancer-cell-specific drug delivery is provided by using the mortalin-binding activity of a single-chain antibody (scFv) wherein L-chain and H-chain variable regions both having the paratope region are linked together via a peptide linker. Also, the sequence of 6 amino acids of an epitope to be recognized by an anti-mortalin antibody having the internalizing function was determined. With the use of an expression vector comprising a nucleic acid that encodes the epitope, an agent for accelerating internalization of a mortalin antibody, a drug bound thereto, and the like into cancer cells is provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11427826-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10800844-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11667710-B2 |
| priorityDate |
2007-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |