| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7e1d859a849b1914105888e68e430351
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_15cc4b540001c45baa07c1cfbe4567a0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_164be846df0094115d7199335a2f5dfd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e4e2fa597ed2c5c18ee696a8e2b90e3d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18d92c46f60af8af24e262b67381d7eb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-141
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2330-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-11 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2007-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49f16df3abb0b96676a771f00033fdf6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7edc4886bf191dad446ae35584c9d595
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8223a0e86395d63332053cdf9780aca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9cd960a3469181bf067da457358a6eb8 |
| publicationDate |
2013-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8586725-B2 |
| titleOfInvention |
MicroRNAome |
| abstract |
MicroRNAs (miRNAs) are a class of small noncoding RNAs that have important regulatory roles in multicellular organisms. The public miRNA database contains 321 human miRNA sequences, 234 of which have been experimentally verified. To explore the possibility that additional miRNAs are present in the human genome, we have developed an experimental approach called miRNA serial analysis of gene expression (miRAGE) and used it to perform the largest experimental analysis of human miRNAs to date. Sequence analysis of 273,966 small RNA tags from human colorectal cells allowed us to identify 200 known mature miRNAs, 133 novel miRNA candidates, and 112 previously uncharacterized miRNA* forms. To aid in the evaluation of candidate miRNAs, we disrupted the Dicer locus in three human colorectal cancer cell lines and examined known and novel miRNAs in these cells. The miRNAs are useful to diagnose and treat cancers. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11472847-B2 |
| priorityDate |
2007-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |