Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f47c750954e13a1ed0be96c1bf1c51c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a71bd57c0b978bc2e6dd663ade1ac9de http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12fbe0b479fb572476ec5d674dc5ab23 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-16134 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-24143 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5256 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-16151 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-60 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-285 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-245 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-863 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-285 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-245 |
filingDate |
2010-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2013-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e78f8539d49271497ecba3457d3ba470 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_518ca3231c9ded8afbd7bfc100d67ff8 |
publicationDate |
2013-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-8580276-B2 |
titleOfInvention |
Genetically stable recombinant modified vaccinia ankara (rMVA) vaccines and methods of preparation thereof |
abstract |
A vaccine comprising an immunologically effective amount of recombinant modified vaccinia Ankara (rMVA) virus which is genetically stable after serial passage and produced by a) constructing a transfer plasmid vector comprising a modified H5 (mH5) promoter operably linked to a DNA sequence encoding a heterologous foreign protein antigen, wherein the expression of said DNA sequence is under the control of the mH5 promoter; b) generating rMVA virus by transfecting one or more plasmid vectors obtained from step a) into wild type MVA virus; c) identifying rMVA virus expressing one or more heterologous foreign protein antigens using one or more selection methods for serial passage; d) conducting serial passage; e) expanding an rMVA virus strain identified by step d); and f) purifying the rMVA viruses from step e) to form the vaccine. One embodiment is directed to a fusion cytomegalovirus (CMV) protein antigen comprising a nucleotide sequence encoding two or more antigenic portions of Immediate-Early Gene-1 or Immediate-Early Gene-2 (IEfusion), wherein the antigenic portions elicit an immune response when expressed by a vaccine. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019084018-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11690908-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11717568-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10376575-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017020938-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10596254-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021062221-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10603375-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9974854-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11116834-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9675689-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9090673-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9931395-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014065181-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018075794-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11541114-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015216965-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017070613-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005158336-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10987420-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10842864-B2 |
priorityDate |
2009-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |