| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d44f48f0f9a08aab31d695a63c53fcbb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07c9542186133097bd6bbb7d92393090
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8846ea2172c1f6a465115193360d45f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4918d2e3b07252dae0ed907273a7fd24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_db3a00483fee98ae7bad42ee260f558d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-00 |
| filingDate |
2012-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80eb4cf46e3f0bc1880e27f8c7c27c91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75a47ee09a4bb22455af2543f8775bea
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd1ae0bfb341c25bfc6c0c5333463991
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58f26e90f2d07dd0e2c64677720201c8 |
| publicationDate |
2013-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8569457-B2 |
| titleOfInvention |
Cytotoxic ribonuclease variants |
| abstract |
Cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex are disclosed. Also disclosed is the 3-D structure of the hRI·RNase 1 complex and methods for designing the RNase 1 variants. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11472864-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017044424-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11286469-B2 |
| priorityDate |
2005-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |