Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b6bbee82108ad927eddffb12f4e186bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96cbb2a26d2c554c07e00731716f2215 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cea139ad438b9ce7d33159d45b154c6b |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-01017 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-24075 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46 |
filingDate |
2009-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2013-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf998381608fcc60a2764e127950f07d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e4be9dfa63769d9ecb889e71729b1b0 |
publicationDate |
2013-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-8568714-B2 |
titleOfInvention |
Lys K endolysin is synergistic with lysostaphin against MRSA |
abstract |
Multi-drug resistant superbugs are a persistent problem in modern health care. LysK is a staphylococcal bacteriophage endolysin from the phage K. It is a peptidoglycan hydrolase enzyme that can lyse many staphylococcal strains and thus is a potent antimicrobial against S. aureus , including MRSA. Lysostaphin is a bacteriocin secreted by S. simulans to kill S. aureus , and has been shown to also be a potent antimicrobial for many antibiotic resistant strains of S. aureus . This study describes optimal reaction conditions for the recombinant His-tagged LysK protein, compares its MIC and antimicrobial activity to lysostaphin and demonstrates synergy when the two are used in combination against the MRSA USA300. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11541106-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2022296686-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9814766-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11717561-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9365625-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11633348-B2 |
priorityDate |
2008-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |