| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_02c28920b0de63f2dc0fda7bc8fe8fcf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d25fcad3dfe2651713fb3dfaf4fca7d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a8046369912ae730134d1762f23d0415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_df874e3cf88adba3792dc9d5b5776180 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2007-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15f7552c8a41a0529d0e4b786e527ddb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6355625c9587e4943f7a1f7e0be46a8b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4255dd180ab1604ad0c563f67acefbc |
| publicationDate |
2013-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8557517-B2 |
| titleOfInvention |
Toll like receptor 4 dysfunction and the biological applications thereof |
| abstract |
The present invention relates to an in vitro method of assessing the sensitivity of a subject to a treatment of cancer, which method comprises detecting the presence of a mutated Toll Like Receptor 4 (TLR4) nucleic acid or an abnormal TLR4 protein expression or activity in a sample from the subject, the presence of said mutated TLR4 nucleic acid or abnormal TLR4 expression or activity being indicative of a resistance to said treatment. The invention further provides compounds for treating or preventing a cancer in a subject having a mutated TLR4 nucleic acid or an abnormal TLR4 protein expression or activity. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10961561-B2 |
| priorityDate |
2006-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |