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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02
filingDate 2012-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2013-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ba9088828d1f723233d84008ad20a01
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publicationDate 2013-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-8546551-B2
titleOfInvention Method to detect prostate cancer in a sample
abstract The present invention provides methods to detect prostate cancer by detecting the RNA encoded by PCA3. The disclosure provides a method for determining a predisposition, or presence of prostate cancer comprising: (a) contacting a sample with at least one oligonucleotide that hybridizes to a PCA3 polynucleotide; (b) detecting an amount of PCA3 and second prostate-specific polynucleotides; and (c) comparing the amount of PCA3 polynucleotide that hybridizes to the oligonucleotide to a predetermined cut off value, and determining the presence or absence of prostate cancer. Diagnostic kits are provided for detecting prostate cancer or the risk of developing same comprising: (a) at least one container means containing at least one oligonucleotide probe or primer that hybridizes to PCA3 (b) at least one oligonucleotide probe or primer that hybridizes with a second prostate specific nucleic acid; and (c) reagents for detecting PCA3 and the second prostate specific nucleic acid.
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