| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d7ab7cf39d1e9e75496dec2e09d8bf21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bca41eda70a68a5dba594ff409e12c3b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_264acb9fb71956599dbf218ffea30426 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-067
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-167 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 |
| filingDate |
2010-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b238296a849b8f9a3638c991badcb813
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7fdf9e90243f5cd36b5ce661fa6516c1 |
| publicationDate |
2013-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8541569-B2 |
| titleOfInvention |
Phosphoramidites for synthetic RNA in the reverse direction, efficient RNA synthesis and convenient introduction of 3'-end ligands, chromophores and modifications of synthetic RNA |
| abstract |
The present invention provides building blocks and methods for synthesizing very pure RNA in a form that can efficiently be modified at the 3′ end. Reverse RNA monomer phosphoramidites have been developed for RNA synthesis in 5′→3′ direction, leading to very clean oligo synthesis that allows for the introduction of various modifications at the 3′-end cleanly and efficiently. Higher coupling efficiency per step have been observed during automated oligo synthesis with the reverse RNA amidites disclosed herein, resulting in a greater ability to achieve higher purity and produce very long oligonucleotides. The use of the reverse RNA phosphoramidites in the synthetic process of this invention leads to oligonucleotides free of N+1 species. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11021503-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015322433-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9718855-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11597744-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019175126-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10550385-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015039053-A2 |
| priorityDate |
2008-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |