| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_13d5d0ccdb4c35ecb65e5fc2e29a11f2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f0c376126a033582ad1376ea1f9fbb59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d2594a404093a4255fea9475ab9eccae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c087e175e59219159d7612387fe16012
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53087f0de62a43b7edbd69f25cb2c8ae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d18af96c795e36c953cfa9628ef905c1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-06008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23J1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 |
| filingDate |
2005-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25e1eb2ccd565f8aafbd5b0e2649255e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2cd74ae6cf109e155effad2ee5d12872
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c087506995942cc273ab0f2ab0618090
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_046be46f1189a2260f233812608c4c4c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_875e21023779f90eff76519c6308debd |
| publicationDate |
2013-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8536315-B2 |
| titleOfInvention |
Production and purification of recombinant arylsulftase |
| abstract |
The present invention pertains to a process for production of recombinant arylsulfatase A in a cell culture system, the process comprising culturing a mammalian cell capable of producing rASA in liquid medium in a system comprising one or more bio-reactors; and concentrating, purifying and formulating the rASA by a purification process comprising one or more steps of chromatography. Other aspects of the invention provides a pharmaceutical composition comprising rASA, which is efficiently endocytosed via the mannose-6-phosphate receptor pathway in vivo as well as a rhASA a medicament and use of a rhASA for the manufacture of a medicament for reducing the galactosyl sulphatide levels within target cells in the peripheral nervous system and/or within the central nervous system in a subject. A final aspect of the invention provides a method of treating a subject in need thereof, said method comprising administering to said subject a pharmaceutical composition comprising a rhASA and thereby obtaining a reduction in the galactosyl sulphatide levels in target cells within said subject. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11407984-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10870837-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9713634-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10336992-B2 |
| priorityDate |
2004-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |