http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8518886-B2

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assignee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4419151f58c7ae749f88e2065fdd6058
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b537903e07982da81c8ea081da33597f
classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-49
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-06
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-05
filingDate 2011-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2013-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f580c90678f74f18aebbb002b00ea6d
publicationDate 2013-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-8518886-B2
titleOfInvention Cytoprotective thereapeutic agents for the prevention of reperfusion injury following ischemic stroke
abstract The present invention relates generally to the use of γ-glutamyl antioxidants, particularly γ-glutamyl-cysteine, as cytoprotective agents to prevent reperfusion injury (i.e., hemorrhagic transformation) of the blood-brain barrier during reperfusion following an ischemic stroke. The γ-glutamyl antioxidants can be used alone or used in combination with an agent which inhibits the reverse movement of Na/Ca exchange in the blood-brain barrier such as 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulphonate (KB-R7943).
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9532961-B2
priorityDate 2005-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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