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filingDate 2012-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2013-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-8501707-B2
titleOfInvention Mucin antigen vaccine
abstract Provided are expression vectors for generating an immune response to a mucin. The vectors comprise a transcription unit encoding a secretable polypeptide, the polypeptide comprising a secretory signal, a mucin antigen and CD40 ligand. Also provided are methods of generating an immune response against cells expressing a mucin by administering an effective amount of the vector. Further provided are methods of generating an immune response against cancer cells expressing a mucin in an individual by administering an effective amount of the vector. Still further provided are methods of overcoming anergy to a mucin self antigen by administering an effective amount of the vector.
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