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filingDate 2010-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2013-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c4f0b3088220f4fdbfa6f8740a7b5b9
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publicationDate 2013-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-8501428-B2
titleOfInvention Single molecule detection platform, manufacturing method thereof and method using the same
abstract A single molecule detection platform is disclosed. The single molecule detection platform comprises a light-transmissive substrate, a plurality of spherical particles and a thin film. The surface of the light-transmissive substrate is etched to form a plurality of cone-shaped structures. Each spherical particle is disposed on top of each cone-shaped structure. The sizes of the plurality of spherical particles are suitable to allow only a single protein to be attached to each spherical particle. The thin film is deposited on the surface of the plurality of cone-shaped structures and acts as a reflective layer of one-dimensional waveguide. The plurality of spherical particles is not covered by the thin film.
priorityDate 2009-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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