| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fc8e3afbfcf74ffac2aeccd8e3b0eee2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f2d101ec1c2e1e497762ba78477c13a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7a2d0f49deccf616cbc41c99cba3f228
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ea5950cfa34dd1cf60942873bde37f96
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_66c1b22707b0276e3078713a6ddcba91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5a81187ef064fdf2c7edf257ee3acc79
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_16d015fa4c454e317beb863a9d50c272 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6416
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K17-00 |
| filingDate |
2011-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9672fad2da7687efc67761e5971b3c44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bbc0c48e17a81043db8cf89674993e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32f6bfd435ee83a317c068f3fe66898f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e4eb928601ae666202d03a39fb13f39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4479d6ad3ddbf87e9e37d593d56ce0e9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95fd3c80de122521f4429066f4579b25 |
| publicationDate |
2013-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8492522-B2 |
| titleOfInvention |
Matrix metalloproteinase 11 vaccine |
| abstract |
Compositions comprising matrix metalloproteinase 11 (MMP-11) or stromelysin-3 (ST-3) or the nucleic acid encoding the MMP-11 for use in vaccines for treating tumors and cancers, which overexpress MMP-11, are described. In particular embodiments, the compositions comprise a nucleic acid encoding a fusion polypeptide that includes the catalytically inactivated MMP-11 linked at the C-terminus to an immunoenhancing element wherein the codons encoding the MMP-11 and the immunoenhancing element have been optimized for enhanced expression of the fusion polypeptide in human cells. In other embodiments, the compositions comprise the catalytically inactivated MMP-11 linked at the C-terminus to an immunoenhancing element. The compositions can be used alone or in synergy with vaccines against other tumor associated antigens as well as with conventional therapies such as radiation therapy and chemotherapy. |
| priorityDate |
2005-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |