| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc501d28c86face12b6c6e4bdf499866
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_45c3f5f39be73e5da988d72ac8577df0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b517b0186af18347d5c058b0c93d877e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b37e3ae3fa7de26a36f636cc71b32986
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7487dc2539734c4d442b96e8ff7c07d4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_144853852824446ab97559a68ca32760 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-102 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1241
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-07 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 |
| filingDate |
2012-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61031490d322353509823478048a6999
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98b4c8339e40f94a169f919cd98fc91c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5119f61276f96a4c86cdcca425debdd9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ddc619a057ce696b558cd45ee7c6c40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1b4695fc5c42991c34358b5072fc8bf |
| publicationDate |
2013-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8486678-B2 |
| titleOfInvention |
Pharmaceutical compositions for the treatment of virus infection |
| abstract |
The invention describes novel pharmaceutical compositions for the treatment of virus infections and cancer. The pharmaceutical compositions include mutant oligoadenylate synthetases (OAS) that have either enhanced cell permeability, reduced oxidative potential, improved antiviral activity, improved enzymatic activity, or absent enzymatic activity. The pharmaceutical compositions have improved drug properties and retain or have enhanced antiviral activity relative to their native forms. The pharmaceutical compositions further include chemically modified oligoadenylate synthetases, such chemical modifications being designed to increase serum stability and reduce immunogenicity in vivo. Such chemical modifications further increase drug stability and manufacturability in vitro. Compositions composed of more than ninety novel modifications are described. Also described are antibodies to polypeptides of the invention. |
| priorityDate |
2005-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |