| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_48c87ff26430f8ab51ec630507b3842c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_59c6a921f33fe0adc58c2b6177184515
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_47864f42e8e57d6699f4dce44e88ddca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8dcf0275e6c17e77579d95897dbfe964
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b3127c0ebee3f865b211b019fac84286
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8076a512205b3b288fb358212ddcdabf |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4196
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-41
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-045
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 |
| filingDate |
2011-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_761b526f428769b617678b4720bfa82d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d4c2c296dd75218b5f7869b868af11a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_beb153644a1d45516adae7e263a4aee7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fb35d58e79a80256d763d2ed29b3e96 |
| publicationDate |
2013-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8466157-B2 |
| titleOfInvention |
Proteasome inhibitors having chymotrypsin-like activity |
| abstract |
Disclosed herein is the use of HLM-008182, as well as its analogues formed via in-house synthesis, as a potent proteasome inhibitors. A new method was developed for HLM-008182 through a four-step protocol and the method was further optimized to a two step protocol. The synthesis in both protocols was regioselective with TiCl 4 . The reaction was highly efficient with microwave assisted heating and THF as solvent. The modification around the molecule HLM-008182 established primary SAR, indicating that the proteasome inhibition activity was a function of the 2-side chain. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10941141-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10941146-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014080843-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10227345-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10208043-B2 |
| priorityDate |
2009-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |