| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_764eb520da0e9df70b5737a119077f6e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_596652f9dd0bc1f2f5de91949fb01ae7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6310f9872a650e799a0648f35bab1a59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5326a9e623f5c9126e735bd057fe978b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| filingDate |
2009-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d31b71fef8130690f9543992eaa9e230
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_634c8a0d69f7173febc7beb45a945c8b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8c0b76a812234c9d6e98b6498b9b248 |
| publicationDate |
2013-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8460673-B2 |
| titleOfInvention |
Fusion protein inhibiting osteoclast formation, preparation method and medicine compositions thereof |
| abstract |
The present invention provides a coding gene having the nucleic acid sequence shown as SEQ ID NO:1 and the fusion protein RIG (SEQ ID NO:2) that inhibits osteoclast formation. The present invention also provides the preparation method for the fusion protein RIG as well as synthetic oligo-nucleotide primers, plasmids and host cells used in the method and a medicine having the above fusion protein RIG as active ingredient. The fusion protein RIG in present invention is derived from humanized immunoglobulin and RANKL with a flexible hinge region. RIG can cross link the cell surface receptor RANK and Fcγ 1 to induce a cytosolic inhibitory signal leading to the inhibition of osteoclast formation. The fusion protein RIG in present invention can play an essential role in treating osteoporosis and bone resorption diseases caused by tumor metastasis. |
| priorityDate |
2008-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |