| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a236e7214b48066926668128d3542edf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0aad734c1853736eb4b1edd17bab554c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b9d0c82c6254d5b4bec8c96e45c9db7b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0522f3bbba77c2c65bf9983bccff1f40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ede4c895254bb8b95f383669891a9ce9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_57ff7af620c792d20fc4987ae9474f3b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-127 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 |
| filingDate |
2009-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c59296bb0bc1258bac6f9599a645f19b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ac39745802c6318a11151d8d4646bb8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa3fb812a1e4346fd2b4b4f6b0c5da2f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2473d90e31acbe869148f832a848a96a |
| publicationDate |
2013-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8455229-B2 |
| titleOfInvention |
RNA polymerase derived from influenza virus |
| abstract |
The present invention aims to express influenza virus RNA polymerase on a large scale, to crystallize the influenza virus RNA polymerase, and to provide a method for screening a substance capable of serving as an active ingredient in anti-influenza drugs which target a protein highly conserved among influenza virus species. n The present invention provides a complex comprising a polypeptide consisting of an amino acid sequence at positions 239-716 of the RNA polymerase PA subunit in influenza A/Puerto Rico/8/1934 H1N1 and a polypeptide consisting of an amino acid sequence at positions 1-81 of the RNA polymerase PB1 subunit in influenza A/Puerto Rico/8/1934 H1N1, as well as a method for screening a substance capable of serving as an active ingredient in anti-influenza drugs, which comprises the step of selecting a substance which inhibits the interaction between α-subunit and β-subunit 1, each constituting influenza virus RNA polymerase, in the presence of a candidate substance. |
| priorityDate |
2008-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |