| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0161fb759d70e445e84701399c0defc0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a2d7f345d14f5903432ce63f57db0654
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e72422fdb66224b1628a30ac28065969
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7828928085917f69d46e2168a49781b7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a4d66b3a7228a73bd2b9cf165ace61fc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_acbd07b56a140659aefe31d92da16803 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-68 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2010-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_daea39592b1630ec7fde00b262371e8a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad7e1b30a17e1f9f223f488e80842dae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6efc2414065dfa3cc165aca9bffc5beb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6ddcf0bbc2e8f06d067113f53f9d339
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5f1bf1d5069ae4203190770c1538c51 |
| publicationDate |
2013-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8431341-B2 |
| titleOfInvention |
Compositions and methods for the identification of inhibitors of protein synthesis |
| abstract |
Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA and the target molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA molecule and the target molecule. High throughput assays are also provided. |
| priorityDate |
2006-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |