| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_997f32fa88ac09ebc096681a2e000fd3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4b4e252b36f75d1a531924df23a2bb31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b66b86852b9a10dfa413d7b0188704cf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6d64153e243152e5f255d74bb64a4c0e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4a13006b1ba46bb813c7096ab333514c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c8a31956f4c0f108a5cd5b4d13734cc7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6811
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6811
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-00 |
| filingDate |
2009-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eae3301f9f6df49a3bdc40fd61cd1448
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1017df2175294e9ba30108ce1f326e78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff404bad08aacc8cb8e13bbcb2b0f048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1fc2a2d5d71f83a82e973fa84e1d1ada
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78d40ba0b9fa91e50e232c5f23a91f84 |
| publicationDate |
2013-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8431132-B2 |
| titleOfInvention |
Recombinant human EPO-FC fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo |
| abstract |
A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention, the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo. In one embodiment the hinge region is a human Fc fragment variant having a non-cysteine residue at amino acid 6. The invention also relates to nucleic acid and amino acid sequences encoding the fusion protein and transfected cell lines and methods for producing the fusion protein. The invention further includes pharmaceutical compositions comprising the fusion protein and methods of using the fusion protein and/or the pharmaceutical compositions, for example to stimulate erythropoiesis in subjects in need of therapy. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-030454-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10487128-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009297522-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016178087-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015005748-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013224198-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11028398-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9375487-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10117949-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11279742-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016178089-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10233223-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020053661-A1 |
| priorityDate |
2006-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |