http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8426136-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d28c8a5c72a9e5fb2e76026b5d4cadad http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6c6088a06f5f9e807e68013d7a0f7b62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b01fe9d0143b5743334e397449d5e021 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2010-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2b3c4c51d9756afab8497c98f5e0941 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a55ab048e616a79a2fb89fcba5ae27c3 |
| publicationDate | 2013-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8426136-B2 |
| titleOfInvention | Epigenetic modifications at TNFα as biomarkers for sensitivity to Smac mimetic-induced apoptosis |
| abstract | The invention provides a method for determining sensitivity of a cell population to apoptosis induced by Smac mimetics as a single agent or in combination with other chemodrugs, which method comprises assaying for an epigenetic modification at the TNFα locus in the cell population as compared to the TNFα locus in a cell population not sensitive to apoptosis induced by Smac mimetics as a single agent or in combination with other chemodrugs, wherein the presence of the epigenetic modification indicates that the cell population is sensitive to apoptosis induced by Smac mimetics as a single agent or in combination with other chemodrugs. |
| priorityDate | 2009-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.