| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_85acbcf556e8a2b3023ab70f44e199c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b85aa7afe8f29e03429596f9c4b2b858
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_63f23d74cd46eddda13b91f258f34425
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3ab9b9f04889f8a56c1f592a4269bc51 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00637
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00621
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00617
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00612
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6458
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00351
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00317
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00722
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00725 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-552
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y30-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y40-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-54353
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-54393 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B32B13-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B32B27-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B32B9-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate |
2008-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60c7e00976147ce387b1cc951911a09b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1033c92847e4e1f22a5f9b8fa03a7054
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea1e53b437ca5c8018eb132e5b628b5e |
| publicationDate |
2013-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8426028-B2 |
| titleOfInvention |
Preparation of sensors on oligo- or poly (ethylene glycol) films on silicon surfaces |
| abstract |
A sensor that includes a) a silicon (Si) substrate having a surface; and b) a monolayer of oligoethylene glycol (OEG) bonded to the surface via silicon-carbon bonds. Regions of the OEG monolayer distal to the surface are functionalized with a ligand serving as a recognition element for a bioanalyte. The ligand is covalently bonded in these regions as a cycloadduct of a 1,3-dipolar cycloaddition reaction. A method of making a silicon surface that recognizes a biological specimen includes 1) hydrosilylating with a mixture that includes an oligoethylene glycol (OEG) substituted with an alkene at one end of the OEG and capped at the opposing end of the OEG and an oligoethylene glycol (OEG) substituted with an alkene at one end of the OEG and an alkyne having a protecting group at the opposing end of the OEG and 2) removing the protecting group from the alkyne; and 3) reacting the alkyne with a reagent in a 1,3-dipolar cycloaddition. The reagent in the 1,3-dipolar cycloaddition includes a portion capable of being recognized by a biological specimen. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014167295-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11275030-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10564107-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10928315-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11262359-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9725529-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8803296-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9150410-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11573177-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9487397-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013324738-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014329392-A1 |
| priorityDate |
2004-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |