| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1cded773b744dccc9ae1e2affdf3e29d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03dbd4a28db5f9da3f2809b3d31f66cc |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-10002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-11001 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 |
| filingDate |
2010-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26bd7fc178ae0d341c65470ebc612071 |
| publicationDate |
2013-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8415315-B2 |
| titleOfInvention |
Methods and compositions for inhibiting the proliferation of cancer cells |
| abstract |
A method of decreasing the expression of LIM kinase 1 in a cancer cell comprising; providing an oligonucleotide consisting of the sequence of SEQ ID NO: 1; providing a cancer cell comprising an mRNA encoding LIM kinase 1; and introducing the oligonucleotide into the cancer cell, wherein the oligonucleotide decreases the expression of LIM kinase 1 in the cancer cell. The method also provides compositions of an antisense RNA LIM kinase 1 that can be administered to an individual for the purpose of inhibiting a protein kinase pathway and which further comprises methods for treating and monitoring the proliferation and metastasis of cancer cells. A kit may be used in the detection and treatment of cancer. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10105365-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9333204-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9532972-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8802649-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10201541-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10201584-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9744170-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015258093-A1 |
| priorityDate |
2004-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |